Women with Elevated Second Trimester Human Chorionic Gonadotropin Level Are at Increased Risk for Preeclampsia*
نویسندگان
چکیده
In current screening test for Down’s syndrome (namely maternal serum alpha-fetoprotein-AFPhuman chronic gonadotropinhCG-, unconjugated estriol plus maternal age) an elevated level of hCG is an important predictor of fetal aneuploidy (1). The positive predictive value of the multiple marker screening test is approximately 4.3% (2). Besides Down’s syndrome, triploidy, trophoblastic diseases, and multiple gestations have been associated with elevated hCG levels (3). In the majority of cases the cause of the elevated maternal hCG levels is not known. hCG is produced by placental trophoblasts and excreted directly into the maternal circulation, and its is possible that abnormal levels are an early sign of placental dysfunction.
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